Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST)

Summary

This article introduces osteoarthritis (OA) as a prevalent condition associated with aging and explores the relationship between epigenetic age acceleration, measured by various clocks, and knee, hand, and multi-joint OA in a study of 671 participants from the Multicenter Osteoarthritis Study. The findings reveal little evidence for significant associations between epigenetic age acceleration and OA, emphasizing the complexity of the relationship between biological aging and OA in different joints.